Physics for sciences of life

Structure and stability of composite gels based on collagen and carboxymethylcellulose

Yu. A. Nashchekina^ab, V. A. Konson^a, M. Yu. Sirotkina^a, A. V. Nashchekin<sup>b

a</sup> Institute of Cytology Russian Academy of Science, 194064 Saint-Petersburg, Russia
^b Ioffe Institute, 194021 Saint-Petersburg, Russia

Abstract: The creation of biocompatible gels, based on type I collagen is studied. To improve the mechanical properties, 10–30% carboxymethylcellulose (CMC) was added to the collagen gel. It is shown that with an increase in the CMC content up to 30%, the stability of composite gels increases. With the help of scanning electron microscopy it is shown, that the ability of collagen to form native fibrils decreases with the addition of CMC. It was also shown by electrophoresis that the presence of CMC increases the rate of degradation of the composite collagen gel.

Keywords: type I collagen, carboxymethylcellulose, composite collagen gels, degradation.

Received: 31.08.2022
Revised: 05.10.2022
Accepted: 06.10.2022

DOI: 10.21883/JTF.2022.12.53764.221-22

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