I. N. Saraeva, E. R. Tolordava, R. A. Khmelnitsky, S. N. Shelygina, D. S. Pozdnyakova, A. A. Nastulyavichus, E. N. Rimskaya, A. E. Rupasov, “Effect of selenium, copper and silver microparticles obtained in viscous media on the gram-positive and gram-negative bacteria survival”, Pis'ma v Zh. Èksper. Teoret. Fiz., 2025, Volume 121, Issue 4,Pages <nobr>321

This article is cited in 3 papers

BIOPHYSICS

Effect of selenium, copper and silver microparticles obtained in viscous media on the gram-positive and gram-negative bacteria survival

I. N. Saraeva^a, E. R. Tolordava^a, R. A. Khmelnitsky^a, S. N. Shelygina^a, D. S. Pozdnyakova^b, A. A. Nastulyavichus^a, E. N. Rimskaya^a, A. E. Rupasov^a

^a Lebedev Physics Institute, Russian Academy of Sciences, Moscow, 119991 Russia
^b National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, 115409 Russia

Abstract: The work presents a multiparametric analysis of the effect of antibacterial nanogels based on nano- and (sub)microparticles of silver, copper and selenium on single- and multicomponent biofilms of gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, as well as gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Nanogels are based on glycerol, silicone oil and Vaseline, which are low-costing biocompatible materials, suitable for use in wound dressings. The active components are bactericidal Ag, Cu, and Se nanoparticles. Nanogels and their effect on the bacterial biofilms were studied by standard microbiological inoculations, as well as Fourier transform infrared spectroscopy methods, followed by principal component analysis. After the treatment of biofilms with nanogels, a decrease in the bacterial population up to 99% was observed. Principal component analysis demonstrated the ability to differentiate viable from nonviable bacteria.

Received: 10.12.2024
Revised: 13.12.2024
Accepted: 13.12.2024

DOI: 10.31857/S0370274X25020245