BIOCOMPUTER SCIENCE AND MEDICINE

Bioinformatics and search of reading frame shifts in genes

M. A. Korotkova^a, E. V. Korotkov<sup>ab

a</sup> Moscow Engineering Physics Institute (National Nuclear Research University)
^b Centre "Bioengineering", Russian Academy of Sciences

Abstract: The definition of a phase shift of triplet periodicity (TP) is introduced. The mathematical algorithm for detection of a phase shift of TP in nucleotide sequences has been developed. The gene sequences from the Kegg-46 data bank were have been analyzed to search for genes with TP phase shifts. The presence of a phase shift of triplet periodicity for 27417 genes (0.7% from the total number of genes in the Kegg-46 data bank) has been demonstrated. We show that TP phase shifts are determined by the shifts of a reading frame in genes. The connection between phase shifts of TP and frame shifts in genes is discussed.

Keywords: triplet periodicity, open reading frame, shifts.