Physics

Morphological changes in transplanted sarcoma S45 at photodynamic therapy using nanocomposites based on gold nanorods

A. B. Bucharskaya^a, È. A. Genina^bc, A. N. Bashkatov^bc, G. S. Terentyuk^a, N. A. Navolokin^a, G. N. Maslyakova^a, N. G. Khlebtsov^d, B. N. Khlebtsov^d, V. V. Tuchin<sup>bce

a</sup> Saratov State Medical University named after V. I. Razumovsky
^b Saratov State University
^c Tomsk State University
^d Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov
^e Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov

Abstract: Photodynamic therapy (PDT) of cancer is an advanced application of gold nanostructures. The purpose of the research is to study the morphological changes in the transplanted sarcoma S45 at PDT using nanocomposites based on gold nanorods (GNRs). GNRs synthesized with the germ method and covered by a silicon coating, functionalized by hematoporphyrin, were intratumorally injected in rats with transplanted sarcoma S45. The tumor was irradiated by He-Ne laser with a wavelength of 632.8 nm. A day later, the animals were withdrawn from the experiment, and the tumor tissue was sampled for morphological studies. After PDT, expressed necrobiotic changes on the background of the inflammatory reaction were observed in transplanted tumors.

Keywords: gold nanorods, photodynamic therapy, transplanted sarcoma S45.

UDC: 616-006.04; 616-018; 535.361; 53.06

DOI: 10.18500/1817-3020-2015-15-4-22-27