This article is cited in 1 paper

Physics

Morphological changes in the internal organs and implanted liver tumor after intravenous injection of gold nanorods in rats with diabetes and transplanted tumor

A. B. Bucharskaya^a, G. S. Terentyuk^a, G. N. Maslyakova^a, O. V. Matveeva^a, N. A. Navolokin^a, N. I. Diht^a, N. G. Khlebtsov^b, B. N. Khlebtsov<sup>b

a</sup> Saratov State Medical University
^b Institute of Biochemisty and Physiology of Plants and Microorganisms RAS

Abstract: The effects of gold nanorods on the internal organs and the transplanted liver tumor were studied in rats with simulated alloxan diabetes and transplanted liver tumors after intravenous administration. Assessed morphofunctional changes and biodistribution of gold in the internal organs and transplanted liver tumor. The study found that a single intravenous injection of gold nanorods does not cause significant morphological changes in the internal organs and transplanted tumors in rats with alloxan diabetes and transplanted tumor. There was a significant accumulation of gold in the spleen and liver of animals in all experimental groups.

Keywords: gold nanorods, alloxan diabetes, transplanted liver tumor.

UDC: 616.379-008.64:57.08:577.29:615: 576.6; 576.33: 616-091.8572:616.716.8(571.5)

DOI: 10.18500/1817-3020-2012-12-2-31-37