MATHEMATICAL MODELING, NUMERICAL METHODS AND PROGRAM COMPLEXES

Development of a modified principal component method to analyse biochemical changes in platelet-rich human plasma during storage

N. A. Vibornov^a, A. Yu. Zyubin<sup>b

a</sup> Immanuel Kant Baltic Federal University, Kaliningrad
^b REC "Fundamental and applied photonics. Nanophotonics" at the Fabrika Scientific and Technological Park of the Immanuel Kant Baltic Federal University

Abstract: The study of biological objects using modern mathematical methods for analysing and classifying vibrational spectra represents an important interdisciplinary aspect at the interface between spectroscopy, biophysics and medical sciences. In this paper, we focus on the use of such methods on the example of platelets and bacteria, which represent complex biological objects, to better understand their structure, properties and potential medical applications. The aim of this work is to study and develop a modified principal component method to analyse biochemical changes in platelet-rich human plasma. This article presents the results of the development of a modified statistical analysis method to analyse the changes in platelet-rich plasma when stored at +5 °С for 6 weeks.

Keywords: vibrational spectra, mathematical methods, Raman scattering, statistical analysis, machine learning, platelets.

Received: 17.12.2024
Revised: 24.01.2025
Accepted: 20.01.2025

DOI: 10.60797/IRJ.2025.151.24