This article is cited in 8 papers

XXV International Symposium Nanophysics and Nanoelectronics, Nizhny Novgorod, March 9-12, 2021
Magnetism

Magnetic nanoparticles obtained by electrophysical technique: focus on biomedical applications

G. V. Kurlyandskaya^ab, A. P. Safronov^ac, S. V. Shcherbinin^ac, I. V. Beketov^ac, F. A. Blyakhman^ad, È. B. Makarova^de, M. A. Korch^f, A. V. Svalov<sup>a

a</sup> Ural Federal University named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia
^b University of the Basque Country UPV-EHU, Department of Electricity and Electronics, Barrio Sarriena s/n, Leioa, 48940, Spain
^c Institute of Electrophysics, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia
^d Ural State Medical University, Yekaterinburg, Russia
^e Ural Institute of Traumatology and Orthopedics, Yekaterinburg, Russia
^f Ural State Agrarian University, Yekaterinburg, Russia

Abstract: This work describes the possibility of fabrication of the large batches of magnetic nanoparticles using electrophysical methods of electric explosion of the wire, laser target evaporation and spark discharge. Bioapplications of nanoparticles require the production of magnetic materials in the form of stabilized aqueous suspensions or hydrogels with magnetic fillers; therefore, some details of the synthesis of these materials and their certification are discussed. The peculiarities of interaction of magnetic nanoparticles with biological systems, the problem of biocompatibility, the possibility of using ferrogel substrates for the needs of cell technologies and regenerative medicine, as well as implication of biomimetics in the development of magnetic biosensors are considered. The results of the analysis of a number of different biological experiments carried out with suspensions of various types, obtained based on the same batch of MNPs are presented. An analysis of examples of magnetic biodetection and existing theoretical approaches will make it possible to assess the prospects of this scientific direction for the creation of highly sensitive thin film sensors based on the giant magnetoimpedance effect for biomedical applications

Keywords: magnetic nanoparticles, iron oxides, ferrogels, electric explosion of the wire, laser evaporation, spark discharge method, thin film nanostructures, detectors of weak magnetic fields, magnetoimpedance, bioapplications.

Received: 09.04.2021
Revised: 09.04.2021
Accepted: 19.04.2021

DOI: 10.21883/FTT.2021.09.51255.17H

 English version: Physics of the Solid State, 2021, 63:10, 1447–1461

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