Polymers

Structure and properties of glycine-nitrate-modified iron oxide nanoparticles for biomedical applications

A. S. Kamzin^a, I. Kozenkov^b, T. Sviridova^b, V. Rodionova^b, A. Omelyanchik<sup>bc

a</sup> Ioffe Institute, St. Petersburg
^b Immanuel Kant Baltic Federal University, Kaliningrad
^c Department of Chemistry and Industrial Chemistry, University of Genova, Italy

Abstract: The properties, structure, and size of iron oxide particles obtained via glycine-nitrate synthesis were studied depending on the amount of glycine in the reaction mixture, ranging from 0.0 mol, 0.1 mol, 0.3 mol, and up to 0.6 mol. Mössbauer spectroscopy data revealed that the synthesized particles are single-phase magnetite ferrite-spinel nanoparticles (Fe$_3$O$_4$). X-ray diffraction and Mössbauer studies indicate that with increasing glycine concentration (0.1 mol, 0.3 mol, and 0.6 mol), the particle sizes decrease from 11 nm, 10 nm, and down to 6 nm, respectively. Mössbauer data indicate differences in the magnetic structures of the surface layer and the bulk of the particles, which significantly affects the properties of the nanoparticles. An approach has been developed to create special iron oxide nanoparticles for the diagnosis and therapy (theranostics) of human diseases.

Keywords: magnetic nanoparticles, functionalization, magnetic properties, magnetic structure.

Received: 21.09.2025
Revised: 21.09.2025
Accepted: 29.09.2025

DOI: 10.61011/FTT.2025.09.61629.259a-25

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