This article is cited in 24 papers

Magnetism

Single-domain magnetic nanoparticles in an alternating magnetic field as mediators of local deformation of the surrounding macromolecules

Yu.I. Golovin^abc, S. L. Gribanovskii^a, D. Yu. Golovin^a, N. L. Klyachko^bc, A. V. Kabanov<sup>bc

a</sup> Research Institute "Nanotechnology and Nanomaterials", Tambov State University
^b Lomonosov Moscow State University
^c Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, USA

Abstract: The forces, deformations, and stresses generated in macromolecules attached to single-domain magnetic nanoparticles under the influence of a low-frequency (nonheating) magnetic field have been analyzed analytically and numerically. It has been shown that, in bioactive macromolecules, an alternating magnetic field with an induction of 0.1–1.0 T and a circular frequency of $\lesssim$ 10$^4$ s$^{-1}$ can induce forces up to several hundred piconewtons, absolute deformations up to a few tens of nanometers, as well as compressive and shear stresses exceeding 10$^7$ Pa. These mechanical stimuli are sufficient for a significant change of interatomic distances in active centers, conformation of macromolecules, and even a breaking of some bonds, which makes it possible to develop a new technological platform for targeted delivery of drugs, remote control of their activity, and cancer-cell destruction.

Received: 21.01.2014

 English version: Physics of the Solid State, 2014, 56:7, 1342–1351

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