This article is cited in 7 papers

ANALYSIS AND MODELING OF COMPLEX LIVING SYSTEMS

Mathematical model of tumor growth with migration and proliferation dichotomy

A. V. Kolobov^a, A. A. Anashkina^b, V. V. Gubernov^a, A. A. Polezhaev<sup>a

a</sup> Lebedev Physical Institute, Leninskiy av. 53, Moscow, GSP-1, 19991, Russia
^b Engelhardt Institute of Molecular Biology RAS, Vavilov str. 32, Moscow 119991, Russia

Abstract: Mathematical model of infiltrative tumour growth taking into account transitions between two possible states of malignant cell is investigated. These transitions are considered to depend on oxygen level in a threshold manner: high oxygen concentration allows cell proliferation, while concentration below some critical value induces cell migration. Dependence of infiltrative tumour spreading rate on model parameters has been studied. It is demonstrated that if the level of tissue oxygenation is high, tumour spreading rate remains almost constant; otherwise the spreading rate decreases dramatically with oxygen depletion.

Keywords: tumor growth, proliferation and migration dichotomy.

Received: 16.04.2009

DOI: 10.20537/2076-7633-2009-1-4-415-422