ANALYSIS AND MODELING OF COMPLEX LIVING SYSTEMS

Interaction of cytokine LIF with the lipidic matrix of membranes

M. P. Borisova^a, L. M. Mezhevikina^b, R. R. Petrova<sup>b

a</sup> Institute of Experimental and theoretic biophysics RAS, 3 Institutskaya str., Pushchino, Moscow region, 142290, Russia
^b Institute of Biophysics of Cell RAS, 3 Institutskaya str., Pushchino, Moscow region, 142290, Russia

Abstract: Integration of LIF protein into the bilayer lipid membrane causes the formation of ion channels. The data on activity of ion channels formed by recombinant protein from mouse and human origin are shown. Also the difference in the effect of LIF protein from eukaryotic and prokaryotic origin is shown.

Keywords: LIF (Leukemia Inhibitory Factor), recombinant protein, ion channel.

UDC: 576.3

Received: 15.03.2010

DOI: 10.20537/2076-7633-2010-2-1-43-49